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. 2021 Sep 8;12:689966. doi: 10.3389/fimmu.2021.689966

Table 6.

Multivariate Cox regression model to predict the risk of the development of adverse outcomes (progression and death) in patients with COVID-19.

Variable Hazard ratio 95% Confidence interval P
Severe COVID-19 4.18x104 1.34x104-1.31x105 <0.0001
Critical COVID-19 5.35x105 1.71x105-1.67x106 <0.0001
Body mass index 1.17 1.02-1.07 0.001
Neutrophil/lymphocyte ratio 1.05 1.02-1.07 <0.0001
Troponin I (pg/mL) 1.002 1.001-1.003 0.002
Lactate deshydrogenase (AU) 1.003 1.00-1.005 0.024
IP-10 (pg/mL) 1.00 1.00-1.001 0.001
3,4 dihydroxybutanoic acid (AU) 1.45 1.18-1.78 <0.0001
Malic acid (AU) 1.45 1.22-1.73 <0.0001
Citric acid (AU) 0.73 0.59-0.99 0.003
Myoinositol (AU) 0.97 0.95-0.99 0.008
Cystine (AU) 1.13 1.06-1.20 <0.0001