Table 1.
Characteristics of participants according to diabetic status.
| Normal | Screened DM | Known DM | Value of p | |
|---|---|---|---|---|
| n=974 | n=92 | n=188 | ||
| miR-30a-5p(2-ΔCt) | 0.0252 ± 0.0549 | 0.0494 ± 0.0916 | 0.1577 ± 0.2512 | <0.001 |
| miR-30a-5p (2-ΔCt)* | 0.0086 (0.0023;0.0262) | 0.0169 (0.0041;0.0576) | 0.0664 (0.011;0.1858) | <0.001 |
| miR-1299 (2-ΔCt) | 0.0033 ± 0.0108 | 0.0042 ± 0.009 | 0.0264 ± 0.062 | <0.001 |
| miR-1299 (2-ΔCt)* | 0.0007 (0.0001;0.0023) | 0.0009 (0.0003;0.0036) | 0.0046 (0.0012;0.0202) | <0.001 |
| miR-182-5p (2-ΔCt) | 1.457 ± 2.0279 | 2.4347 ± 4.742 | 8.979 ± 11.1365 | <0.001 |
| miR-182-5p (2-ΔCt)* | 0.7994 (0.3065;1.7989) | 1.3223 (0.3966;2.4185) | 4.6079 (1.3219;13.0158) | <0.001 |
| miR-30e-3p (2-ΔCt) | 0.0047 ± 0.0071 | 0.0056 ± 0.0067 | 0.0291 ± 0.0478 | <0.001 |
| miR-30e-3p (2-ΔCt)* | 0.0019 (0.0006;0.0062) | 0.0023 (0.0008;0.0079) | 0.0119 (0.0025;0.041) | <0.001 |
| miR-126-3p (2-ΔCt) | 1.0375 ± 0.9964 | 1.6141 ± 1.324 | 7.2226 ± 7.1824 | <0.001 |
| miR-126-3p (2-ΔCt)* | 0.7251 (0.2917;1.5107) | 1.4188 (0.4404;2.4671) | 4.7558 (1.4091;10.7017) | <0.001 |
| Age (years) | 45.22 ± 15.3 | 58.15 ± 10.62 | 57.88 ± 11.97 | <0.001 |
| Sex, n (%) | ||||
| Female | 688 (70.6) | 73 (79.3) | 151 (80.3) | 0.008 |
| Male | 286 (29.4) | 19 (20.7) | 37 (19.7) | |
| Body mass index (kg/m2) | 27.4 ± 7.8 | 31.5 ± 8.0 | 30.7 ± 6.4 | <0.001 |
| Waist circumference (cm) | 87.9 ± 16.5 | 100.2 ± 15.5 | 99.3 ± 16.5 | <0.001 |
| Hip circumference (cm) | 100.9 ± 16.5 | 108.0 ± 15.4 | 107.0 ± 14.0 | <0.001 |
| Systolic blood pressure (mmHg) | 131 ± 25 | 146 ± 26 | 148 ± 26 | <0.001 |
| Diastolic blood pressure (mmHg) | 84 ± 15 | 90 ± 14 | 88 ± 15 | <0.001 |
| Glucose (Fasting) (mmol/L)* | 4.7 (4.4;5.1) | 7.3 (5.7;8.9) | 9.1 (6.6;13.3) | <0.001 |
| Glucose 2h (mmol/L)* | 5.4 (4.5;6.3) | 12.8 (11.5;16.6) | <0.001** | |
| HbA1c (%) | 5.6 ± 0.5 | 7.3 ± 1.9 | 8.9 ± 2.4 | <0.001 |
| HbA1c (mmol/mol) | 37.5 ± 5.0 | 56.5 ± 21.2 | 73.8 ± 26.6 | <0.001 |
| Insulin Fasting (mIU/L)* | 5.8 (3.7;9.0) | 9.4 (5.45;16.6) | 9.25 (5.48;15.43) | <0.001 |
| Insulin 2h (mIU/L)* | 30.5 (15.9;53.6) | 51.2 (29.2;80.4) | <0.001** | |
| Triglycerides-S (mmol/L)* | 1.1 (0.8;1.5) | 1.4 (1.1;2.4) | 1.6 (1.2;2.2) | <0.001 |
| Cholesterol HDL-S (mmol/L) | 1.4 ± 0.4 | 1.3 ± 0.5 | 1.3 ± 0.3 | 0.039 |
| Cholesterol LDL-S (mmol/L) | 3.1 ± 1,0 | 3.5 ± 1.1 | 3.2 ± 1.1 | 0.001 |
| Cholesterol-S (mmol/L) | 5.0 ± 1.2 | 5.7 ± 1.3 | 5.3 ± 1.2 | <0.001 |
| usCRP (mg/L)* | 3.4 (1.3;7.8) | 6.5 (3.2;13.1) | 4.9 (2.3;10.3) | <0.001 |
| Gamma GT-S * (IU/L)* | 27.0 (19.0;42.0) | 42.5 (26.3;76.0) | 33.0 (20.0;61.0) | <0.001 |
| S-Creatinine (umol/L)* | 59.0 (52.0;68.0) | 61.0 (52.0;77.0) | 60.5 (52.0;75.0) | 0.127 |
| MDRD eGFR (ml/min) | 107.3 ± 30.0 | 93.2 ± 30.7 | 93.9 ± 32.5 | <0.001 |
| CKD-EPI eGFR (ml/min) | 106.3 ± 20.6 | 90.3 ± 23.1 | 90.8 ± 24.1 | <0.001 |
| Education level, n (%) | ||||
| <7years | 271 (28) | 39 (43.3) | 75 (40.3) | <0.001 |
| ≥7years | 698 (72) | 51 (56.7) | 111 (59.7) | |
| Tobacco use, n (%) | ||||
| Non-smoker | 393 (42.1) | 58 (66.7) | 128 (70.3) | <0.001 |
| Current smoker | 540 (57.9) | 29 (33.3) | 54 (29.7) | |
| Alcohol use, n (%) | ||||
| Non-drinker | 645 (66.5) | 76 (83.5) | 161 (86.6) | <0.001 |
| Current drinker | 325 (33.5) | 15 (16.5) | 25 (13.4) | |
Cholesterol HDL-S, serum high-density lipoprotein cholesterol; cholesterol LDL-S, serum low-density lipoprotein cholesterol; cholesterol-S, serum total cholesterol; usCRP, ultrasensitive C-reactive protein; gamma GT-S, serum gamma-glutamyl transferase; S-creatinine, serum creatinine; MDRD eGFR, Modification of Diet in Renal Disease estimated glomerular filtration rate; and CKD-EPI eGFR, Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate.
*
data represented as median (25th–75th percentile).
**
value of p between normal group and screen-detected diabetes only.