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. 2021 Sep 8;11:682917. doi: 10.3389/fonc.2021.682917

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Copyright © 2021 Liu, Zhang, Xu, Liu, Sun, Che and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histamine released by mast cell degranulation stimulates the proliferation of ovarian cancer cells. (A) HE staining of normal ovarian tissue (left) and ovarian cancer tissue (right). (B) Correlation between mast cell infiltration and histamine release in ovarian cancer tissue. (C) Histamine release levels in normal ovarian and ovarian cancer tissues, *P < 0.05 (compared to normal tissues). (D) OVCAR-3 cell proliferation after treatment with different concentrations of histamine. (E) Anglne cell proliferation rate after treatment with histamine at a concentration of 50 ng/mL. *P < 0.05 (compared to untreated Anglne cell group).