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. 2021 Sep 8;11:682917. doi: 10.3389/fonc.2021.682917

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Copyright © 2021 Liu, Zhang, Xu, Liu, Sun, Che and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histamine induces the development of ovarian cancer by disordering expression of estrogen receptors (ERs). (A) Immunohistochemical detection of ovarian tissues, *P < 0.05 (compared to normal tissues). (B) Correlation analysis between histamine and ERα (left)、ERβ (right) in ovarian cancer tissues. (C) Western blot analysis of the expression of ERα and ERβ in histamine-treated OVCAR-3 cells. (D) Effect of Inhibiting or activating of estrogen receptors on the proliferation of OVCAR-3 cells. AZD9496, PHTTP, PPT, DNP are respectively ERα inhibitors, ERβ inhibitors, ERα agonists, ERβ agonists; *P <0.05 (Compared to untreated OVCAR-3 cell group); ^# P < 0.05 (compared with the HA-treated group).