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. 2021 Sep 8;11:682917. doi: 10.3389/fonc.2021.682917

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Copyright © 2021 Liu, Zhang, Xu, Liu, Sun, Che and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apigenin inhibits the tumor-promoting effect of histamine by down-regulating ERα/ERβ. (A, B) The effect of different concentrations of apigenin, AZD9496, and DNP on the proliferation of OVCAR-3 cells. The concentration of AZD9496 and DNP was 1 µM. (C, D) The mRNA expression of ERα (C) and ERβ (D). (E) The protein expression of ERα and ERβ by western blot. *P < 0.05 (Compared to untreated OVCAR-3 cell group); #P < 0.05 (compared with the HA-treated group).