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. 2021 Sep 8;12:730908. doi: 10.3389/fphys.2021.730908

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Copyright © 2021 Milighetti, Shawe-Taylor and Chain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of performance with other published tools. In each violin plot, a dot is an epitope for which performance is calculated. In Case 1, only epitopes that are not present in the PDB or in the VDJDb train sets are included. In Case 2, only epitopes that are present in the VDJDb but not in the PDB are included. In Case 3, only epitopes which are in both training sets are included. To look for differences, a Mann-Whitney U-test was calculated and significance values are shown: *p < 0.05; **p < 0.01; ***p < 0.001.