Table 1.

Discovery and replication of TCF7L2 variants in TAA

Variant	EA	OA	Discovery				Replication				Discovery + replication
			Beta	SE	OR 95% CI	p	Beta	SE	OR 95% CI	p	Beta	SE	OR 95% CI	p
rs4073288 (index)	A	G	−0.25	0.04	0.72–0.84	3.1 × 10−8	−0.07	0.02	0.90–0.97	4.2 × 10−5	−0.10	0.02	0.87–0.94	5.2 × 10−9
rs7904519 (genotyped)	G	A	−0.21	0.04	0.75–0.88	3.6 × 10−7	−0.07	0.02	0.90–0.97	1.7 × 10−5	−0.09	0.01	0.90–0.93	3.3 × 10−9
rs4074718 (fine-mapped)	A	G	−0.23	0.04	0.73–0.86	1.1 × 10−7	−0.07	0.02	0.90–0.97	4.0 × 10−5	−0.09	0.02	0.88–0.95	5.8 × 10−9

EA, effect allele; OA, other allele.