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. 2021 Aug 2;108(9):1611–1630. doi: 10.1016/j.ajhg.2021.07.002

Figure 1.

Figure 1

Fine-mapping of multiple melanoma GWAS signals on chromosome band 7p21.1

(Top) A view of the 7p21.1 locus including UCSC genes, imputed ChromHMM and DNaseI hypersensitivity (DHS) data from two melanocyte cultures generated by the RoadMap Project, ATAC-seq data generated from five human primary melanocyte cultures, and candidate causal variant sets nominated by either conditional analysis or Bayesian fine-mapping (95% credible sets for each of four clusters) with DAP-G. Candidate causal variants mapping to signal/cluster 1 are in red, those mapping to signal/cluster 2 are in green, those mapping to signal/cluster 3 are in blue, and those mapping to signal/cluster 4 are in purple. (Bottom) A zoomed-in view of the region immediately surrounding rs117132860, showing rs117132860 mapping to open chromatin and annotated melanocyte enhancer. Genomic positions are based on hg19. For the zoomed-in region containing rs117132860 (bottom), layered 7-cell H3K27Ac, DHS clusters, and transcription factor CHIP tracks were generated by ENCODE and provided through the UCSC Genome Browser.