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. 2021 Jul 17;120(17):3776–3786. doi: 10.1016/j.bpj.2021.06.039

Table 1.

Binding of TTAPE-Me to the lipid bilayer as a function of the lipid total charge and the charge of headgroup above the phosphate moiety

Lipid type Monomer binding energy (kJ/mol) Dimer binding energy (per monomer) (kJ/mol) Relative binding strength (monomer) Relative binding strength (dimer) Lipid total charge Headgroup charge, excluding phosphate
CL −553.7 ± 3.8 −499.1 ± 3.5 1 1 −2 0
PG −519.6 ± 0.9 −476.2 ± 3.7 0.94 0.95 −1 0
PS −224.9 ± 3.4 −273.2 ± 3.5 0.41 0.55 −1 0 (−1/+1)
PC/PE −9.5 ± 3.4 −15.7 ± 1.4 0.02 0.03 0 +1

The mean binding energies and the standard errors are the same as in Fig. 4F. Relative binding strength is computed in comparison to CL.