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. 2021 Jul 29;8(18):2101454. doi: 10.1002/advs.202101454

Figure 3.

Figure 3

A) Plasmas were isolated at each blood collection, and then analyzed for CAB concentrations by UPLC/MS/MS. Horizontal dotted and dashed lines represent 1  ×  and 4  ×  PA‐IC90, respectively. B) Tissues were collected at each sacrifice day and then analyzed for CAB concentrations by UPLC/MS/MS. LN: lymph node. Reproduced with permission.[ 58 ] Copyright 2018, Elsevier. C) CAB was chemically modified with 14‐, 18‐ and 22‐carbon fatty acid chains to develop MCAB, M2CAB, and M3CAB, respectively. D) Morphological assessment of NCAB, NMCAB, NM2CAB, and NM3CAB by SEM. Reproduced with permission.[ 59 ] Copyright 2020, Nature Publishing Group. E) Layered arrangement of bexarotene prodrug after self‐assembling into a gas‐filled bubble followed by its rupture upon US exposure and interacts favorably with the cancer cell membrane to get inserted and eventually be cleaved enzymatically, releasing the active pharmaceutical ingredient. Reproduced with permission.[ 60 ] Copyright 2015, American Chemical Society.