Table 1.

Factors associated with increased D-dimer (>250 ng/mL) in chronic spontaneous urticaria patients

Parameter	CSU patients with normal D-dimer (=<250 ng/mL) (Total n=95)	CSU patients with raised D-dimer (>250 ng/mL) (Total n=46)	P
Age (years; mean±SD)	34.45±11.87	36.17±11.17	0.41
Sex (F/M)	59/36	29/17	0.91
Duration (months)	45.6±23.8	44.9±22.5	0.85
Presence of angioedema	40 (42.1%)	25 (54.3%)	0.17
History of Atopy	31 (32.6%)	13 (28.3%)	0.59
Presence of thyroid abnormality	10 (10.5%)	5 (12.2%)	1.00
Family history of urticaria	12 (12.6%)	5 (12.2%)	0.76
Positive ASST	37 (38.9%)	18 (39.1%)	0.98
Positive APST	24 (25.3%)	13 (28.3%)	0.70
Mean Serum Ig E (kU/L) (Mean±SD)	440.6±569.12	756.5±1724.41	0.10
Serum Ig E raised (>100 kU/L)	70 (73.7%)	35 (76.1%)	0.75
Mean UAS 0 weeks (Mean±SD)	12.46±4.87	16.45±5.12	<0.001*
Number of patients having mild, moderate and severe grading of baseline UAS7
Mild	27	4	<0.001
Moderate	48	18	*
Severe	20	24
PT (in seconds) (Mean±SD)	11.06±1.34	11.88±1.55	0.002*
PT raised	7 (7.4%)	17 (36.9%)	<0.001*
APTT (in seconds) (Mean±SD)	33.33±3.26	36.48±4.32	<0.001*
APTT raised	4 (4.2%)	18 (39.1%)	<0.001*
Dose of antihistamine required
Single	19	2	<0.001
Two-fold	21	1	*
Three-fold	20	5
Four-fold	35	38
Second-line drugs used	22 (23.1%)	34 (73.9%)	<0.001
Azathioprine	12 (12.6%)	19 (41.3%)	*
Cyclosporine	10 (10.5%)	15 (32.6%)

*Significant P values; +- SD- Standard Deviation