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Influences of α-spectrin isoform on the deformability of RBCs in Hale et al. (2). Left: represents a control red blood cell with αI isoform of spectrin that deforms under shear. Right: represents a red blood cell with αIIβI tetramers that show increased connectivity to the cellular membrane through membrane proteins and a reduced cellular deformability under shear stress. To see this figure in color, go online.
