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. 2021 Sep;100(3):559–569. doi: 10.1016/j.kint.2021.04.034

Figure 2.

Figure 2

The renal hepcidin antimicrobial peptide/ferroportin (FPN) axis contributes to, but is not essential for, normal systemic iron homeostasis under conditions of normal iron availability. (a–d) Systemic iron indexes in female and male FpnC326Yfl/fl,Pax8.CreERT2+ mice and FpnC326Yfl/fl controls at 1 week, 1 month, 3 months, and 6 months after tamoxifen treatment, including (a) serum ferritin, (b) liver iron content, (c) spleen iron content, and (d) hemoglobin. (e–h) Systemic iron indexes in female and male Fpnfl/fl,Pax8.CreERT2+ mice and Fpnfl/fl controls at 1 week, 1 month, 3 months, and 6 months after tamoxifen induction, including (e) serum ferritin, (f) liver iron content, (g) spleen iron content, and (h) hemoglobin. Values are shown as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. ppm, parts per million.