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. 2021 Sep 14;24(5):797. doi: 10.3892/mmr.2021.12437

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Overexpression of HOXC10 partially reverses the inhibitory effect of MTFR2 knockdown on colorectal cancer cell proliferation and migration. (A) Proliferation, (B) clone formation, (C) migration and (D) invasion of HCT116 cells co-transfected with sh-MTFR2-1 and Oe-HOXC10 were in turn detected by the Cell Counting Kit-8, clone formation, wound healing and Transwell assays (magnification, ×100). Relative migration and invasion rates were expressed normalized to the control group. (E) Protein expression levels of invasion- and migration-related proteins in HCT116 cells co-transfected with sh-MTFR2-1 and Oe-HOXC10 were detected by western blotting. **P<0.01 and ***P<0.001 vs. sh-NC; ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. sh-MTFR2-1; ^@P<0.05, ^@@P<0.01 and ^@@@P<0.001 vs. sh-MTFR2-1 + Oe-NC. MTFR2, mitochondrial fission regulator 2; sh, short hairpin RNA; Oe, overexpression; NC, negative control.