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. 2021 Jul 30;144(11):845–858. doi: 10.1161/CIRCULATIONAHA.121.056323

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Primary outcome in EAST-AFNET4 patients with heart failure by randomized groups. Aalen-Johansen cumulative-incidence curves for the effects of early rhythm control on the primary outcome. Primary outcome is defined as a composite of death from cardiovascular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome. A, All patients with heart failure. B, Heart failure with reduced ejection fraction. C, Heart failure with midrange ejection fraction. D, Heart failure with preserved ejection fraction. EAST-AFNET4 indicates Early Treatment of Atrial Fibrillation for Stroke Prevention Trial; and LVEF, left ventricular ejection fraction.