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. 2021 Jul 30;144(11):845–858. doi: 10.1161/CIRCULATIONAHA.121.056323

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Left ventricular function and changes in left ventricular function of EAST-AFNET4 patients with heart failure by randomized groups. Changes in LVEF between baseline and 2 years are given in the overall heart failure population (all patients, Left) and split by LVEF groups (reduced, midrange, and preserved). The numeric changes in LVEF, split by randomized group, were early rhythm control, reduced LVEF 17.28±13.45; usual care, reduced LVEF 18.10±10.73, mean difference –0.83 (–4.44 to 2.79; P=0.66); early rhythm control, midrange LVEF 9.25±10.44; usual care, midrange LVEF 8.68±8.97 (mean difference 0.66 [–1.99 to 3.31]; P=0.63); early rhythm control, preserved LVEF 0.33±8.33; usual care, preserved LVEF –0.93±8.34 (mean difference 0.98 [(–0.83 to 2.79]; P=0.29). EAST-AFNET4 indicates Early Treatment of Atrial Fibrillation for Stroke Prevention Trial; and LVEF, left ventricular ejection fraction.