. 2021 Sep 21;4(9):e2126334. doi: 10.1001/jamanetworkopen.2021.26334

Table 5. Numbers of Hepatocellular Carcinomas and Biliary Tract Cancers Before and During the COVID-19 Pandemic.

Cancer stage	Cumulative, No.		Per month, mean (SD)		Change, %	P value
Cancer stage	Before	During	Before	During	Change, %	P value
Hepatocellular carcinoma
Total	338	75	8.89 (3.17)	7.50 (2.27)	−15.68	.20
Stage I	185	33	4.87 (2.28)	3.30 (2.06)	−32.22	.06
Stage II	70	17	1.84 (1.72)	1.70 (1.49)	−7.71	.81
Stage III	51	16	1.34 (1.12)	1.60 (1.71)	19.22	.66
Stage IV	32	9	0.84 (0.92)	0.90 (1.10)	6.88	.87
Localized^a	286	59	7.53 (2.76)	5.90 (2.08)	−21.61	.09
Regional^a	30	12	0.79 (0.94)	1.20 (0.59)	52.00	.33
Distant^a	22	4	0.58 (0.76)	0.40 (0.70)	−30.91	.50
Biliary tract cancer
Total	268	62	7.05 (3.06)	6.20 (2.25)	−12.09	.42
Stage 0	13	3	0.34 (0.52)	0.30 (0.68)	−12.31	.85
Stage I	49	11	1.29 (1.41)	1.10 (0.99)	−14.69	.69
Stage II	70	23	1.84 (1.48)	2.30 (1.64)	24.86	.40
Stage III	59	12	1.55 (1.37)	1.20 (1.03)	−22.71	.45
Stage IV	77	13	2.03 (1.64)	1.30 (1.16)	−35.84	.20
Localized^b	103	25	2.71 (1.89)	2.50 (1.90)	−7.77	.76
Regional^b	92	25	2.42 (1.46)	2.50 (0.85)	3.26	.87
Distant^b	73	12	1.92 (1.58)	1.20 (1.23)	−37.53	.19

^{^a}

Hepatocellular carcinoma was categorized as localized stage (stage IA, IB, II, or IIIA), regional stage (stage IIIB or IVA), or distant stage (stage IVB).

^{^b}

Gallbladder cancer was categorized as localized stage (stage 0, IA, IB), regional stage (stage IIA, IIB, IIIA, IIIB, or IVA), or distant stage (stage IVB). Hilar cholangiocarcinoma was categorized as localized stage (stage 0 or I), regional stage (stage II, IIIA, IIIB, IIIC, or IVA), or distant stage (stage IVB). Distal cholangiocarcinoma was categorized as localized stage (stage 0, I, or IIA), regional stage (stage IIB, IIIA, or IIIB), or distant stage (stage IV).