Table 1.
Characterization of lesion variables by designated treatment
| Lesions | All n (%) | SDRT n (%) | PMDS n (%) | SDRT vs PMDSP value | SBRT n (%) | PMDS vs SBRT P value |
|---|---|---|---|---|---|---|
| 598 (100) | 292 (49) | 162 (27) | 144 (24) | |||
| Histology | <.001 | .029 | ||||
| Prostate | 143 (24) | 84 (29) | 36 (22) | 23 (16) | ||
| NSCLC | 108 (18) | 56 (19) | 21 (13) | 31 (22) | ||
| CRC | 86 (14) | 43 (15) | 24 (15) | 19 (13) | ||
| Breast | 82 (14) | 26 (9) | 37 (23) | 19 (13) | ||
| Other | 179 (30) | 83 (28) | 44 (27) | 52 (36) | ||
| Lesion site | .06 | <.001 | ||||
| Bone | 193 (32) | 94 (32) | 61 (38) | 38 (27) | ||
| Lymph nodes | 212 (35) | 81 (28) | 47 (29) | 84 (58) | ||
| Liver | 47 (8) | 26 (9) | 16 (10) | 5 (3) | ||
| Lung | 105 (17) | 70 (24) | 26 (16) | 9 (6) | ||
| Soft tissues | 47 (8) | 27 (9) | 12 (7) | 8 (6) | ||
| Lesion volume | <.001 | .21 | ||||
| Median | 5.1 | 4.8 | 6.1 | 7.5 | ||
| Mean ± 1 SD | 15.6 ± 37.8 | 7.9 ± 6.9 | 20.0 ± 36.9 | 27.6 ± 63.8 | ||
| SUVmax | .002 | .81 | ||||
| Median | 9.2 | 6.1 | 7.3 | 10.2 | ||
| Mean ± 1 SD | 6.8 ± 8.4 | 8.1 ± 12.9 | 10.4 ± 10.2 | 7.5 ± 8.7 | ||
| Adjuvant treatment | .76 | .25 | ||||
| Yes | 335 (56) | 158 (54) | 99 (61) | 78 (54) | ||
| No | 263 (44) | 134 (46) | 63 (39) | 66 (46) |
Abbreviations: adjuvant Tx = adjuvant systemic therapy; CRC = colorectal cancer; NSCLC = non-small cell lung cancer; PMDS = dose-sculpted SDRT coverage planned to a PTVPMDS subvolume to comply with radiation tolerance of an adjacent normal organ at risk (rest of the tumor treated with 24 Gy); SBRT = hypofractionated 3 × 9 Gy stereotactic body radiation therapy schedule; SD = standard deviation; SDRT = 24 Gy single-dose radiation therapy covering the whole tumor volume.