eTable 1. Characteristics of the populations in the Kinzig River Valley region, the control regions, and the comparison region Baden-Württemberg.

	Number of insured persons			Age: mean (median)			Sex (% females)			Charlson index*1 (mean)			GISD (mean)
Year	KT	CR 1–13	BW*2	KT	CR 1–13	BW*2	KT	CR 1–13	BW*2	KT	CR 1–13	BW*2	KT	CR 1–13	BW*2
2006	29 226	400 033	311 062	44.0 (44)	43.3 (44)	44.0 (45)	52.4	53.5	53.8	0.43	0.50	0.52	7.51	7.49	7.10
2007	28 698	391 142	307 434	44.3 (45)	43.8 (45)	44.3 (45)	52.2	53.4	53.7	0.39	0.46	0.48	7.36	7.33	6.96
2008	28 331	384 816	301 916	44.7 (45)	44.2 (45)	44.7 (46)	52.2	53.4	53.7	0.36	0.43	0.45	7.21	7.18	6.81
2009	28 208	381 251	299 955	45.0 (46)	44.6 (46)	44.9 (46)	52.1	53.4	53.6	0.34	0.40	0.42	7.09	7.05	6.69
2010	28 716	384 212	302 893	44.9 (46)	44.6 (46)	44.8 (46)	51.9	53.2	53.5	0.31	0.38	0.39	6.97	6.91	6.57
2011	29 041	390 794	308 033	45.0 (46)	44.6 (46)	44.7 (46)	51.8	53.1	53.4	0.29	0.35	0.36	6.84	6.78	6.45
2012	28 965	388 369	304 050	44.9 (46)	44.5 (46)	44.7 (46)	51.7	52.8	53.2	0.28	0.33	0.34	6.72	6.64	6.33
2013	28 649	384 713	300 982	44.9 (46)	44.7 (46)	44.8 (46)	52.2	53.1	53.4	0.26	0.31	0.32	6.59	6.51	6.21
2014	29 073	393 337	309 921	45.2 (47)	44.8 (47)	44.8 (46)	52.1	53.1	53.4	0.24	0.30	0.30	6.47	6.37	6.08
2015	29 206	397 845	314 269	45.2 (47)	44.9 (47)	44.7 (46)	52.1	52.9	53.1	0.23	0.28	0.28	6.34	6.24	5.96

*¹ Charlson comorbidity index in the year of individual entry into the study, averaged over the study population per region and year

*² The comparison region „BW“, i.e., the BW sample without insured persons in Kinzig River Valley, but with insured persons in the control regions.

BW, Baden-Württemberg (here: random sample); GISD, German Index of Socioeconomic Deprivation; CR 1–13, control regions; KT, Kinzig River Valley region