Study	Reason for exclusion
Bentur 1990	Not a randomised controlled trial. No control group.
Bremont 1992	Not a randomised controlled trial. Used infusion rather than inhaled medication.
Closa 1998	No placebo group. Comparison of nebuliser versus inhaler.
Connor 1989	Age range outside specified ‐ up to 36 months. Author contacted for data < 24 months.
Daugbjerg 1993	Heterogenous patient group with recurrent wheeze and bronchiolitis.
De La Luz 1999	Age range beyond specified (0 to 72 months)
Hayden 1998(b)	Not a randomised controlled trial. Not randomised.
Hayden 1998a	Not a randomised controlled trial. Not randomised.
Henderson 1993	Included only healthy infants.
Hickey 1994	Heterogenous patient group with >= 50% having RSV.
Holmgren 1992	Not a randomised controlled trial. Not randomised.
Jackson 1999	Not a randomised controlled trial. No control group.
Lenney 1978	Not a randomised controlled trial. No control group.
Mallol 1987a	Heterogenous patient group with recurrent wheeze and bronchiolitis.
Mallol 1987b	Heterogenous patient group with recurrent wheeze and bronchiolitis.
Naspitz 1992	No placebo group. Comparison of fenoterol plus or minus ipratropium bromide. Some patients on first episode of wheeze only.
O'Callaghan 1986	Not a randomised controlled trial. No control group.
O'Callaghan 1988	Not a randomised controlled trial. Not randomised and no control group.
Orlowski 1991	Not a randomised controlled trial.
Ploin 2000	Age range beyond specified (0 to 60 months)
Prendiville 1987b	Not a randomised controlled trial. Active and placebo treatments given in order.
Prendiville 1987c	Not a randomised controlled trial. Active and placebo treatments given in order.
Radford 1975	Not a randomised controlled trial. No contemporaneous control group.
Rubilar 2000	Heterogenous patient group with recurrent wheeze and bronchiolitis.
Rutter 1975	No a randomised controlled trial. Heterogenous patient group with recurrent wheeze and bronchiolitis.
Schweich 1992	Heterogenous patient group with >= 50% having RSV.
Seidenberg 1991	Not a randomised controlled trial. Phase 1 not controlled. Phase 2 not randomised.
Spier 1985	Abstract only. Probable mixture of recurrent wheeze and bronchiolitis. Study during RSV season.
Tal 1983	Heterogenous patient group with recurrent wheeze and bronchiolitis.