Table 1.
Baseline Characteristics and Physiological Factors at Study Enrollment
| Variable | Overall (n = 209) | Successful Liberation (n = 114) | Failed Liberation (n = 32) | P Value |
|---|---|---|---|---|
| Demographics | ||||
| Age, yr, mean ± SD | 59.7 ± 16.3 | 58.0 ± 17.0 | 57.2 ± 16.5 | 0.82 |
| Sex, n (%) | 1.00 | |||
| M | 139 (66.5) | 79 (69.3) | 22 (68.8) | |
| F | 70 (33.5) | 35 (30.7) | 10 (31.3) | |
| BMI, kg/m2, mean ± SD | 28.9 ± 7.6 | 28.6 ± 8.1 | 29.4 ± 6.2 | 0.59 |
| Ethnicity, n (%) | 0.02 | |||
| Non-Hispanic white | 151 (72.2) | 80 (70.2) | 27 (84.4) | |
| Non-Hispanic Black | 14 (6.7) | 9 (7.9) | 0 (0.0) | |
| Hispanic | 12 (5.7) | 10 (8.8) | 0 (0.0) | |
| Asian/Pacific Islander | 8 (3.8) | 3 (2.6) | 3 (9.4) | |
| American Indian/Alaska native | 1 (0.5) | 0 (0.0) | 1 (3.1) | |
| Other | 23 (11.0) | 12 (10.5) | 1 (3.1) | |
| Chest radiograph infiltrates* | ||||
| Bilateral, n (%) | 199 (95.2) | 107 (93.9) | 30 (93.8) | 1.00 |
| Number of quadrants, mean ± SD | 3 ± 1 | 3 ± 1 | 3 ± 1 | 0.39 |
| Baseline physiologic factors | ||||
| PaO2:FiO2 ratio, mean ± SD | 187.0 ± 92.8 | 189.7 ± 91.0 | 193.8 ± 93.9 | 0.83 |
| Vasopressors, n (%) | 183 (87.6) | 81 (71.1) | 24 (75.0) | 0.29 |
| mSOFA (no GCS), mean ± SD | 9.2 ± 3.4 | 8.2 ± 3.0 | 10.0 ± 4.2 | 0.03 |
| Outcome | ||||
| Ventilated days†, mean ± SD | 8.3 ± 6.7 | 6.0 ± 5.7 | 12.3 ± 8.0 | 0.0002 |
| In-hospital mortality, Day 29, n (%) | 69 (33.0) | 8 (7.1) | 5 (15.6) | 0.16 |
| In-hospital mortality, Day 60, n (%) | 75 (35.8) | 11 (9.6) | 6 (18.8) | 0.21 |
Definition of abbreviations: BMI = body mass index; GCS = Glasgow Coma Scale; mSOFA = modified Sequential Organ Failure Assessment.
Baseline physiologic factors were measured within 24 hours of ICU admission.
*Day 2 chest radiographs were read if enrollment chest radiographs were not present (n = 9).
†Total duration of mechanical ventilation in the first 29 days.