. 2021 Jan 27;60(4):2178–2187. doi: 10.1021/acs.inorgchem.0c02648

Table 1. Cytotoxicity IC₅₀ (μM) and MCR Index at 48 h for 3–5 and CDDP and Platinum–DNA Binding Levels after 2 h Treatment with the Compounds.

complex	A549^a	A549 spheroid	MCR index^b	ng Pt/μg DNA^c
3	5.45 ± 0.22	74.15 ± 1.12	13.6	77.42 ± 10.02
4	1.20 ± 0.13	35.08 ± 1.06	29.2	178.63 ± 29.83
5	1.43 ± 0.04	78.69 ± 1.11	55.0	51.75 ± 5.82
CDDP	0.96 ± 0.19	34.18 ± 1.13	35.6	39.78 ± 6.32

Human alveolar adenocarcinoma cell line.

The multicellular resistance (MCR) index is the ratio of the spheroid and the monolayer culture IC₅₀ values.

Measurements indicate the Pt bound to DNA after 2 h of treatment of A549 cells with 20 μM of the compounds. The results are presented as mean ± SD of 2 independent experiments with 4 replicates each.

Table 1. Cytotoxicity IC50 (μM) and MCR Index at 48 h for 3–5 and CDDP and Platinum–DNA Binding Levels after 2 h Treatment with the Compounds.

Table 1. Cytotoxicity IC₅₀ (μM) and MCR Index at 48 h for 3–5 and CDDP and Platinum–DNA Binding Levels after 2 h Treatment with the Compounds.