Table III.
DCE-MRI parameters and immunohistochemical findings according to the microvessel density and PD-L1 expression.
| Variables | All patients (n=21) | MVD, low (n=10) | MVD, high (n=11) | P-valuea | PD-L1−, (n=9) | PD-L1+low, (n=6) | PD-L1+high, (n=6) | P-valueb |
|---|---|---|---|---|---|---|---|---|
| DCE-MRI parameters | ||||||||
| CI-max | 1.45 | 1.18 | 1.70 | P=0.38 | 1.10 | 1.32 | 2.11 | P<0.05 (P<0.05c) |
| T-max | 64.79 | 76.85 | 53.82 | P<0.01 | 75.66 | 51.55 | 61.72 | P=0.07 |
| CI-peak | 1.31 | 1.06 | 1.53 | P=0.38 | 0.99 | 1.19 | 1.90 | P<0.05 (P<0.05c) |
| CI-gain | 0.97 | 0.71 | 1.22 | P<0.05 | 0.70 | 0.83 | 1.53 | P<0.05 (P<0.05c) |
| IHC staining | ||||||||
| MVD | 51.92 | – | – | 34.67 | 61.51 | 68.20 | P<0.05 (P<0.05c) |
The data are presented as the means.
a
MVD low vs. MVD high via Mann-Whitney U test.
b
PD-L1− vs. PD-L1+low vs. PD-L1+high via Kruskal-Wallis test
c
PD-L1− vs. PD-L1+high via Dunn's test. P<0.05 was considered statistically significant. DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; MVD, microvessel density, PD-L1, programmed death ligand-1; PD-L1−, negative PD-L1; PD-L1+low, low-positive PD-L1; PD-L1+high, high-positive PD-L1; IHC, immunohistochemistry.