Table V.
Multivariate Cox regression analyses for PFS and OS in patients with metastatic colorectal cancer.
| A, PFS | ||||
|---|---|---|---|---|
|
| ||||
| Variable | HR | Lower 95% CI | Upper 95% CI | P-value |
| Liver metastasis (negative vs. positive) | 1.82 | 1.17 | 2.83 | 0.0079b |
| Lymph node metastasis (negative vs. positive) | 2.23 | 1.40 | 3.54 | 0.0007c |
| Grade 3 or 4 neutropenia within the first cycle of treatment (negative vs. positive) | 0.51 | 0.30 | 0.86 | 0.0118a |
|
| ||||
| B, OS | ||||
|
| ||||
| Variable | HR | Lower 95% CI | Upper 95% CI | P-value |
|
| ||||
| ECOG PS (0 vs. 1 or 2) | 2.26 | 1.29 | 3.97 | 0.0043b |
| Liver metastasis (negative vs. positive) | 2.31 | 1.34 | 3.98 | 0.0027b |
a
P<0.05
b
P<0.01
c
P<0.001. PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group Performance Status.