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. 2019 Jul 12;41(2):159–170. doi: 10.1093/carcin/bgz132

Figure 1.

Figure 1.

TFA-rich diet promotes the development of hepatic steatosis, inflammation and tumors in HCVcpTg mice. Male 12-13-month-old HCVcpTg mice on a C57BL/6 genetic background were treated for 5 months with a control diet (Con) or an isocaloric diet that replaced most FA with trans-FA (TFA). (A) Liver tumor prevalence rates, the number and maximal diameter of liver tumors in each mouse and prevalence rates of liver tumors > 3 mm in diameter. (B) Ratio of liver weight to body weight, hepatic content of triglyceride (TG) and non-esterified fatty acid (NEFA) and serum alanine aminotransferase (ALT) levels. (C) Photomicrographs of hematoxylin and eosin-stained liver sections. Bar = 100 μm. More severe macrovesicular steatosis and inflammatory cell infiltration were detected in TFA-rich diet-fed HCVcpTg mice. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001 between control diet-fed and TFA-rich diet-fed HCVcpTg mice.