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CB-5083 inhibits PDE6-mediated cGMP hydrolysis. (A–D) PDE6-mediated cGMP hydrolysis in the absence or presence of vardenafil (red), CB-5083 (green), or sildenafil (blue), with doses ranging from 30 nM to 30 µM. Three technical replicates were performed per condition. Data are plotted as mean ± S.D.
