Table 3.
Allelic distribution of previously known APOC3 rare variants and their association with TG, HDL-C, and CAD only in Asian Indians
| Variant | Carrier | Non-Carrier | % Carriers | Mean TG (mg/dL) Carrier/Non-carrier |
Mean HDL mg/dL Carrier/Non-carriers | CAD Among Carriers | CAD Among Non-carriers | Odds Ratio/CI/P (CAD) |
|---|---|---|---|---|---|---|---|---|
| rs373975305 (IVS1-2G-A) | 12 | 23,871 | 0.05 | 166.6/173.6 (−4%) | 44/42.6 (3.3%) | 0/12 | 4364/19507 | 0.18 95%CI (0.01–3.02); p = 0.233 |
| rs76353203 (R19X) | 3 | 23,880 | 0.01 | 84.9/171.5 (−50.5%) | 55.1/43.3 (27.3%) | 0/3 | 4364/19516 | 0.64 95%CI (0.03–12.37); p = 0.767 |
| rs138326449 (IVS2 + 1G-A) | 4 | 23,879 | 0.02 | 101/165.8 (−39.1%) | 46.7/46.2 (1.1%) | 0/4 | 4351/19528 | 0.50 95%CI (0.03–9.26); p = 0.641 |
| rs147210663 (A43T) | 22 | 23,861 | 0.09 | 175.2/171.5 (2.2%) | 42.7/43.4 (−1.6%) | 0/22 | 4364/19497 | 0.09 95%CI (0.01–1.64); p = 0.106 |
| rs140621530 (IVS3 + 1G-T) | 12 | 23,871 | 0.05 | 221/173.6 (27.3%) | 43/42.6 (0.9%) | 0/12 | 4364/19507 | 0.18 95%CI (0.01–3.02); p = 0.233 |
Variant data from Singapore Asian Indians (MEC_ Indian and SINDI) were not included because of the lack of information on CAD