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. 2021 Sep 22;19:96. doi: 10.1186/s12964-021-00776-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Integrator together with NACK activates Notch-mediated transcription. a MS/MS analysis shows that subunits of the Integrator complex co-purify with the Notch Ternary Complex in the Notch-driven T-cell lymphoma cell line 4084 by affinity chromatography. Notch-independent lymphoma 6780 was used as a negative control. b Representative ChIP on the HES1, HES4, and CCND1 promoters in OE19 EAC. Bars represent standard deviation (N = 3). c Expression of Notch1 target genes in OE19 and OE33 upon INTS11 knockdown. Bars represent standard deviation (the mean from 3 biological replicates). **p < 0.01 versus CTR sample. d Expression of Notch1 target genes in OE19 and OE33 upon NACK knockdown. Bars represent standard deviation (the mean from 3 biological replicates). **p < 0.01 versus CTR sample