Fig. 5.

Integrative analysis of Roseburia effects on the phenylalanine metabolism pathway (KEGG ko00360). A Total abundances of enzymes encoded by MSPs in the Roseburia genus, with MSP 112 highlighted in the black box. B Observed enzymes and compounds in the phenylalanine pathways. Compounds and enzymes in blue and orange groups are colored accordingly. Significant Spearman correlations between enzymes encoded by Roseburia and phenylalanine metabolism compound intensities. Only the top matching compound name is shown. Compound enzyme groups are indicated by orange and blue bars. The black line emphasizes the separation between the two groups. C Correlation between total abundances of enzymes and average intensities of compounds grouped by blue and orange bars in B. D Null distribution of correlations between selected compounds and random groups of six (blue group) or five genes (orange group) from the Roseburia genomes. Observed Spearman correlations (as in C) are marked with a black vertical line and the null distribution is shown in gray. E Phenylalanine metabolism pathway (KEGG ko00360). Detected compounds and enzymes are colored in blue and orange