Figure 1.

B7-H3 is highly expressed on pediatric solid tumors. A, Pediatric tumor microarrays were stained by IHC for the expression of B7-H3. Representative images of Ewing sarcoma (3+), glioblastoma multiforme (3+), medulloblastoma (2+), and alveolar rhabdomyosarcoma (3+, 2+, and 1+) samples are shown. H-scores were generated by multiplying the % cells positive × intensity seen for each core. H-scores are shown for pediatric sarcomas (B), neuroblastoma and Wilms tumor (C), and pediatric CNS tumors (D). RMS, rhabdomyosarcoma; EWS, Ewing sarcoma; DIPG, diffuse intrinsic pontine glioma.