Table 1.
Expression of B7-H3 on pediatric tumors by IHC
| Intensity | ||||||
|---|---|---|---|---|---|---|
| Tumor type | # Stained | Positive (%) | 3+ (%) | 2+ (%) | 1+ (%) | 0 (%) |
| Alveolar rhabdomyosarcoma | 12 | 92% | 25% | 50% | 17% | 8% |
| Embryonal rhabdomyosarcoma | 10 | 100% | 40% | 60% | 0% | 0% |
| Ewing sarcoma family of tumors | 27 | 89% | 30% | 15% | 44% | 11% |
| Wilms tumor | 12 | 100% | 67% | 33% | 0% | 0% |
| Neuroblastoma | 186 | 82% | 28% | 29% | 25% | 18% |
| Ganglioneuroblastoma | 25 | 60% | 8% | 4% | 48% | 40% |
| Ganglioneuroma | 11 | 36% | 0% | 9% | 27% | 64% |
| Medulloblastoma | 46 | 96% | 61% | 22% | 13% | 4% |
| High-grade glioma (WHO grade 3/4) | 37 | 84% | 35% | 16% | 33% | 16% |
| Diffuse intrinsic pontine glioma | 22 | 100% | 45% | 32% | 23% | 0% |
| Total | 388 | 84% | 34% | 25% | 25% | 16% |