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. Author manuscript; available in PMC: 2022 Aug 18.
Published in final edited form as: ACS Chem Neurosci. 2021 Aug 3;12(16):3049–3059. doi: 10.1021/acschemneuro.1c00340

Figure 3.

Figure 3.

KU-596 improves mtBE in ex vivo MQC diabetic neurons. (A) Basal OCR was measured in sensory neurons prior to the addition of oligomycin (a), FCCP (b), and rotenone/antimycin A (c). ND, nondiabetic. (B) Effect of treatments on MRC and SRC. *, p = 0.047 and 0.039 versus ND-MRC and ND-SRC, respectively; #, p < 0.001 and 0.004 versus STZ-MRC and STZ-SRC, respectively. Symbols are responses from pooled neurons in each well that were isolated from lumbar DRG of 3–6 mice per group. (C) Drug treatment increased energy metabolism in diabetic neurons.