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KU-596 does not improves mtBE in ex vivo MQC × Txnip KO diabetic neurons. (A) Basal OCR was measured in sensory neurons prior to the addition of oligomycin (a), FCCP (b), and rotenone/antimycin A (c). ND, nondiabetic. (B) Effect of treatments on MRC and SRC. *, p < 0.001 vs ND-MRC or ND-SRC; #, p = 0.002 versus ND-MRC. Symbols are responses from pooled neurons in each well that were isolated from the lumbar DRG of 3–6 mice per group.
