Table 1.
Baseline characteristics of patients recruited from Europe and China
| Characteristic | Europe | China |
|---|---|---|
| Sex, F:M, n | 29:10 | 15:2 |
| Age, yr | 49 (14.5) | 30 (11.0) |
| BMI, kg/m2 | 27.2 (6.0) | 23.3 (4.2) |
| Chinese, n | — | 17 |
| White, n | 37 | — |
| South Asian, n | 2 | — |
| Iron, μmol/L | 12.2 (10.2) | 9.0 (6.0) |
| Ferritin, μg/L | 17.0 (21.8) | 11.0 (7.0) |
| sTfR, nmol/L | 39.1 (24.4) | — |
| Hepcidin, ng/ml | 1.4 (4.1) | — |
| Hemoglobin, g/dl | 13.7 (2.7) | 13.0 (2.9) |
| NYHA functional class, n | |
|
| I | 1 | 1 |
| II | 20 | 12 |
| III | 18 | 4 |
| 6MWD, m | 427.0 (85.0) | 462.0 (118.0) |
| Dyspnea score (Borg index) | 2.8 (2.0) | 1.0 (2.5) |
| NT-proBNP, ng/L | 127.3 (335.8) | — |
| Systolic blood pressure, mm Hg | 112.0 (16.5) | 106.0 (10.0) |
| Diastolic blood pressure, mm Hg | 68.0 (11.5) | 70.0 (8.0) |
| PVR, Wood units | 6.7 (3.9) | 9.3 (3.3) |
| mPAP, mm Hg | 47.0 (8.5) | 49.0 (16.0) |
| mRAP, mm Hg | 10.0 (7.5) | 3.0 (6.0) |
| mPAWP, mm Hg | 11.0 (2.8) | 7.0 (5.0) |
| Cardiac index, L/min/m2 | 2.6 (1.2) | 2.7 (0.7) |
| Treatment, n | |
|
| PDE-5 inhibitor | 33 | 13 |
| Endothelin receptor antagonist | 29 | 7 |
| Prostacyclin | 10 | 1 |
| Calcium channel blocker | 2 | — |
| Warfarin | 26 | 9 |
| Diuretics | 24 | 17 |
| Digoxin | 4 | 2 |
| Sodium ferulate | — | 16 |
Definition of abbreviations: 6MWD = 6-minute walk distance; BMI = body mass index; mPAP = mean pulmonary arterial pressure; mPAWP = mean pulmonary artery wedge pressure; mRAP = mean right atrial pressure; NT-proBNP = N-terminal–pro hormone brain natriuretic peptide; NYHA = New York Heart Association; PDE-5 = phosphodiesterase type 5; PVR = pulmonary vascular resistance; sTfR = soluble transferrin receptor.
All continuous variables are median (interquartile range).