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. Author manuscript; available in PMC: 2021 Sep 22.
Published in final edited form as: Org Biomol Chem. 2020 Apr 8;18(14):2739–2746. doi: 10.1039/d0ob00223b

Scheme 10.

Scheme 10

Reagents and conditions; (i) (a) elicosadienoic acid, Et3N, isopropyl chloroformate (1 M in tol), anhyd. CH2Cl2, rt, 50 min; (b) rt to 0 °C; (c) 32, DMF, 0 °C to rt, 3 h; (ii) Ac2O, DMAP, o/n, 86%; (iii) 2.5 M NaOMe, MeOH, rt, 3 h, 88%.