Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reagents and conditions; (i) (a) Me3P (1 M in THF), anhyd. THF, 0 °C to rt, 5 h; (b) NaOH (2 M), o/n, quant. (ii) (a) EDCI·HCl, HOBt, C25H51COOH, 10 : 4 CH2Cl2 : DMF, rt, 30 min; (b) 18, DIPEA, anhyd. CH2Cl2, rt, o/n, 81% over two steps. (iii) Pd/C, CH2Cl2/MeOH H2, rt, o/n, 92%.
