Scheme 1.

Synthesis of R IPP and reaction with boron trifluoride diethyletherate to obtain R IPP_BF2 . i) 2‐Acetylpyridine:aldehyde:NH4OAc 1 : 2 : 5; AcOH, r.t., 7 days. ii) BF3⋅Et2O, Et3N, CH2Cl2, r.t.

Synthesis of R IPP and reaction with boron trifluoride diethyletherate to obtain R IPP_BF2 . i) 2‐Acetylpyridine:aldehyde:NH4OAc 1 : 2 : 5; AcOH, r.t., 7 days. ii) BF3⋅Et2O, Et3N, CH2Cl2, r.t.