Table 4.

Logistic regression models of single and combined parameter analysis predicting ABMR in DSA⁺ recipients.

Comparison*	Likelihood ratio	P value	AUC (combined variables)	AUC (single variable)
Cohort 1
Model 1
dd‐cfDNA vs. [dd‐cfDNA + DSA‐MFI]	5.50	0.008	0.92	0.90 (dd‐cfDNA)
dd‐cfDNA vs. [dd‐cfDNA + serum creatinine]	0.72	0.38	0.89
dd‐cfDNA vs. [dd‐cfDNA + protein/creatinine ratio]	3.59	0.19	0.88
Model 2
DSA‐MFI vs. [DSA‐MFI + dd‐cfDNA]	19.1	<0.0001	0.93	0.88 (DSA‐MFI)
DSA‐MFI vs. [DSA‐MFI + serum creatinine]	3.10	0.78	0.85
DSA‐MFI vs. [DSA‐MFI + protein/creatinine ratio]	11.2	<0.001	0.89
Cohort 2
Model 1
dd‐cfDNA vs. [dd‐cfDNA + DSA‐MFI]	9.96	0.001	0.84	0.68 (dd‐cfDNA)
dd‐cfDNA vs. [dd‐cfDNA + serum creatinine]	0.10	0.72	0.63
dd‐cfDNA vs. [dd‐cfDNA + protein/creatinine ratio]	0.23	0.13	0.74
Model 2
DSA‐MFI vs. [DSA‐MFI + dd‐cfDNA]	4.83	0.028	0.83	0.79 (DSA‐MFI)
DSA‐MFI vs. [DSA‐MFI + serum creatinine]	3.09	0.79	0.80
DSA‐MFI vs. [DSA‐MFI + protein/creatinine ratio]	0.28	0.60	0.75

ABMR, antibody‐mediated rejection; dd‐cfDNA, donor‐derived cell‐free DNA; DSA, donor‐specific antibody.

*For logistic regression analysis, dd‐cfDNA levels and protein/creatinine ratios were log transformed.