TABLE 2.
Measures of diagnostic accuracy for peanut allergy of specific IgE to Ara h 2 at different cut‐off levels
| Patients | N |
Cut‐off kUA/L |
Sensitivity % (95% CI) |
Specificity (95% CI) |
PPV % (95% CI) |
NPV % (95% CI) |
LR+ Ratio (95% CI) |
LR‐ Ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|
| All children† | 113 | 0.1 | 100 (92.8–100) | 53.1 (38.4–67.2) | 74.3 (62.4–82.0) | 100 (84.0–100) | 2.13 (1.58–2.87) | 0 (NA) |
| 5.0 | 53.1 (40.3–65.5) | 98 (87.8–100) | 97.1 (83.4–100) | 61.5 (49.8–72.1) | 26.03 (3.69–183.60) | 0.48 (0.37–0.62) | ||
| Secondary care | 77 | 0.1 | 100 (90.2–100) | 59.4 (40.8–75.8) | 77.6 (64.4–87.1) | 100 (79.1–100) | 2.46 (1.62–3.74) | 0 (NA) |
| 5.0 | 48.9 (33.9–64.0) | 96.9 (82.0–99.8) | 95.7 (76.0–99.8) | 57.4 (43.3–70.5) | 15.64 (2.22–110.19) | 0.53 (0.40–0.70) | ||
| Tertiary care | 36 | 0.1 | 100 (79.1–100) | 41.2 (19.4–66.5) | 65.5 (45.7–81.4) | 100 (56.1–100) | 1.70 (1.14–2.53) | 0 (NA) |
| 5.0 | 63.2 (38.6–82.8) | 100 (77.1–100) | 100 (69.9–100) | 70.8 (48.8–86.6) | Infinity | 0.37 (0.20–0.66) |
Abbreviations: CI, confidence interval; LR‐, negative likelihood ratio; LR+, positive likelihood ratio; n, number; NA, not applicable; NPV, negative predictive value; PA, peanut allergy; PPV, positive predictive value.
†
Included children with a reference test with a conclusive outcome n = 113/150 (75%)