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. 2021 Jul 16;60(33):18022–18030. doi: 10.1002/anie.202101478

Figure 4.

Figure 4

Blood‐brain barrier penetration and evaluation in rodent model of Parkinsonism. a) Brain‐to‐plasma ratio of compound 30 determined in rats (24 mg kg−1). Data represent mean±SD. b) Bar graph of the number of net rotations (contralateral‐ipsilateral rotation count, 30 min) induced by DMSO (17 %)/saline (n=6) or compound 30 (n=7, 24 mg kg−1, IP) dissolved in DMSO (17 %)/saline. **P<0.01 accordingly to Mann‐Whitney test. c) Bar graph of the number of net rotations (30 min) induced by DMSO (17 %)/saline (n=6), raclopride (n=7, 2 mg kg−1, IP), compound 30 (n=7, 24 mg kg−1, IP) or the combination of raclopride and compound 30 (n=7) dissolved in DMSO (17 %)/saline. *P<0.05 accordingly to One‐way ANOVA followed by Tukey's multiple comparisons test. Data represent mean±SEM.