Table 2.

Comparison of different microfluidic platforms for single-cell nucleic acid analysis

Platforms	Advantages	Limitations
Valve-based	Controllability of each step Functional integration	Low throughput Complicated chip fabrication Complicated system
Microwell-based	Straightforward operation Compatibility with other protocols	Cross contamination Uncontrollable cell number
Droplet-based	High throughput Concise system	Elaborated flow control
Centrifugal-based	Flexible flow control Parallel processing	Limited throughput Complicated system
Digital microfluidics	Controllability of each step Parallel processing	Limited throughput Complicate system