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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Ann Neurol. 2021 Jul 22;90(3):353–365. doi: 10.1002/ana.26153

Figure 2: LARGE-PD GWAS results.

Figure 2:

A. Manhattan plot of log-transformed p-values by chromosome. P-values were obtained via a logistic mixed model adjusting for age, sex, and the first five principal components using the GENESIS package in R. The significant peak is located within SNCA on chromosome 4. The suggestive peak one near chromosome 3 is near NRROS. B. QQ-plot of GWAS p-values. GC lambda was 1.017. C. Locuszoom-style plot of the chromosome 4 locus using LARGE-PD linkage disequilibrium data.