Table 1.

Activity of de novo designs 1, 2, and 3 on RORs in Gal4 hybrid reporter gene assays. Data are reported as mean±S.E.M., n≥4.

	IC50 [μm]
Structure and ID	RORα	RORβ	RORγ
	>10	>10	4.6±0.5
	23±3	22±1	0.37±0.05
	10±1	7.6±0.5	0.68±0.07