FIGURE 2.

Body weight in CTEP‐ and vehicle‐treated SOD1^G93A and WT mice. The body weight loss was measured as an index of disease progression in CTEP‐ and vehicle‐treated SOD1^G93A or WT male and female mice, at low‐dose (2 mg·kg⁻¹ every 48 h) or high‐dose (4 mg·kg⁻¹ every 24 h) CTEP. Animals were weighed 3 days a week starting on Day 80 of life. Data in (a) are means ± SEM of 15 low‐dose CTEP‐treated and 15 vehicle‐treated SOD1^G93A male mice and of five low‐dose CTEP‐treated and five vehicle‐treated WT male mice. Data in (b) are means ± SEM of 15 low‐dose CTEP‐treated and 11 vehicle‐treated SOD1^G93A female mice and of five low‐dose CTEP‐treated and five vehicle‐treated WT female mice. Data in (c) are means ± SEM of 14 high‐dose CTEP‐treated and 14 vehicle‐treated SOD1^G93A male mice and five high‐dose CTEP‐treated and five vehicle‐treated WT male mice. Data in (d) are means ± SEM of 12 high‐dose CTEP‐treated and 11 vehicle‐treated SOD1^G93A female mice and five high‐dose CTEP‐treated and five vehicle‐treated WT female mice. *P < 0.05, significantly different from CTEP‐ or vehicle‐treated WT mice, respectively; ^# P < 0.05, significantly different from vehicle‐treated SOD1^G93A mice; two‐way ANOVA followed by Tukey's post hoc test