Figure 1.

The PharmGKB curation process. Blue boxes represent primary literature and source documents that are curated. Green boxes represent basic PharmGKB annotations derived from curated literature and documents. Orange boxes represent PharmGKB annotations based on aggregated and evaluated basic annotations and curated literature. CPIC, Clinical Pharmacogenetics Implementation Consortium; DPWG, Royal Dutch Association for the Advancement of Pharmacy‐ Pharmacogenetics Working Group; EMA, European Medicines Agency; FDA, US Food and Drug Administration; HCSC, Health Canada (Santé Canada); PD, pharmacodynamics; PharmGKB, Pharmacogenomics Knowledgebase; PK, pharmacokinetics; PMDA, Pharmaceuticals and Medical Devices Agency, Japan; VIPs, Very Important Pharmacogenes.