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. 2021 Jul 29;60(35):19483–19490. doi: 10.1002/anie.202107158

Scheme 1.

Scheme 1

Mechanism of A) NCL and B) auxiliary‐mediated peptide ligation. Structure of C) reported auxiliaries and D) the new 2‐mercapto‐2‐(pyridin‐2‐yl)ethyl‐(MPyE)‐auxiliary.