Table A1.

The wish‐list used to automatically generate the FMO plans using Erasmus‐iCycle, containing a list of constraints and a list of prioritized planning objectives.

Constraints
Priority	Volume	Dose metric	Limit (Gy)
	PTV	Dmax	61.5
	UrethraPlan	D5%	45
		D10%	42
		Dmean	40
	Rectum	Dmax	38
		D1cc	32.3
	Rectum mucosa	Dmax	27
	Bladder	Dmax	41.8
		D1cc	38
	Penile bulb	Dmax	1.5
	Ring PTV 2–3cm	Dmax	25
	Skin dose	Dmax	20
	Shell 3 mm	Dmax	38
	Shell 3 cm	Dmax	20
	Shell 5 cm	Dmax	20

Objectives
Priority	Volume	Dose metric	Goal	Sufficient	Parameters
1	PTV ‐ OARs	$\downarrow$ LTCP	0.01	0.01	$D^p$ = 37 Gy, $\alpha$ = 0.90
2	PTV	$\downarrow$ LTCP	0.25	0.25	$D^p$ = 37 Gy, $\alpha$ = 0.60
3	UrethraPlan	$\downarrow$ Dmean	39 Gy	38 Gy
4		$\downarrow$ LTCP	0.50		$D^p$ = 40 Gy, $\alpha$ = −0.50
5	Rectum	$\downarrow$ LTCP	0.00		$D^p$ = 27 Gy, $\alpha$ = −0.20
6	Bladder	$\downarrow$ LTCP	0.00		$D^p$ = 31 Gy, $\alpha$ = −0.20
7	Dose bath	$\downarrow$ Dmax	15 Gy
8	Femoral heads	$\downarrow$ Dmax	24 Gy

The optimization starts with optimizing on the PTV to attain sufficient PTV coverage, while respecting all constraints from the constraints list. Once an objective is optimized, it is added as an additional constraint to the constraint list and then the next objective will be optimized. The relative ranking of the objectives is based on clinical importance of the structures. A detailed description of the Erasmus‐iCycle workflow is provided in Breedveld et al., 2012.¹⁸ UrethraPlan is defined as the volume of the urethra within the PTV.