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Main stages of human embryogenesis/liver organogenesis (left panel) mimicked and recapitulated in protocols for hPSCs into hepatocytes (right panel). Pathways involved during human liver embryogenesis are indicated in green. Abbreviations: BMP, bone morphogenic protein; CK19, cytokeratin 19; CXCR4, chemokine (C‐X‐C motif) receptor 4; GATA4, GATA binding protein 4; HGF, hepatocyte growth factor; HNF, hepatocyte nuclear factor; SOX17, SRY (sex determining region Y)‐box 17.
