Scheme 5.
C[D3]methylation of alcohols and nitriles. Reaction conditions: a) Me3NO (0.1 equiv.), NaOH (2 equiv.), 130 °C, 24 h; b) NaOH (0.1 equiv.), NaOtBu (1 eq.), tBuOH, 110 °C, 40 h; c) NaOtBu (3 equiv.), 150 °C, 24 h.
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