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. 2021 Sep 8;13:689939. doi: 10.3389/fnagi.2021.689939

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Copyright © 2021 Hu, Huang, Ma, Li, Zhao, Zheng, Li, Wang, Sun and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of serum pituitary adenylate-cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) levels with disease duration and disease severity in PD patients. (A) Serum PACAP levels were negatively correlated with disease duration (Spearman’s correlation coefficient r = –0.257, P < 0.05, and n = 72). (B) Serum VIP levels were negatively correlated with UPDRS part III scores (Pearson’s correlation coefficient r = –0.256, P < 0.05, and n = 72).